INDOMETHACIN

SynDRA canonical compound SYN0000013 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	PTGS2
Mechanism of action	Cyclooxygenase inhibitor
Indication	ankylosing spondylitis \| bursitis \| osteoarthritis \| rheumatoid arthritis \| tendinitis
Disease area	orthopedics \| rheumatology

All known targets

PTGS2
PTGS1
PTGDR2
PPARG
SLC46A1
GLO1
PLA2G2A
Ptgs2
Ptgs1
Ptgds
Ptgdr2
PTGR2

Mechanisms of action (all sources)

Cyclooxygenase inhibitor
PTGS2 INHIBITOR
PTGS1 INHIBITOR
PTGDR2 FULL AGONIST
PPARG PARTIAL AGONIST
SLC46A1 INHIBITOR
PTGS2 MODULATOR

Drug classes

Cyclooxygenase Inhibitors
Analgesics
Analgesics, Non-Narcotic
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Antirheumatic Agents
Cardiovascular Agents
Enzyme Inhibitors
Gout Suppressants
Peripheral Nervous System Agents
Reproductive Control Agents
Sensory System Agents

ATC classes

C01E · OTHER CARDIAC PREPARATIONS
M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
S01B · ANTIINFLAMMATORY AGENTS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION

Cross-references

PubChem CID: 3715
ChEMBL: CHEMBL6
DrugBank: DB00328
ChEBI: CHEBI:49662
KEGG: D00141
RxNorm: 5781
PDB: IMN
Wikipedia: Indometacin
TTD: D0R1RS
LINCS BRD: BRD-K57222227

Synonyms

Reported adverse events

Bleeding
GI bleed
Perforation
Ulceration
Elderly
Thrombophlebitis
Stevens-Johnson syndrome
Hypertension
Headache
Hepatotoxicity
Pruritus
Asthma

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