IMIPRAMINE

SynDRA canonical compound SYN0000042 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	SLC6A4
Mechanism of action	Norepinephrine reputake inhibitor
Indication	depression \| nocturnal enuresis
Disease area	neurology/psychiatry \| urology

All known targets

SLC6A2
SLC6A4
CHRM2
KCNH1
HRH1
KCNH2
DRD2
CHRM5
CHRM4
CHRM1
HTR2A
CHRM3

Mechanisms of action (all sources)

Serotonin reuptake inhibitor
Norepinephrine reputake inhibitor
SLC6A4 INHIBITOR
Serotonin transporter inhibitor
SLC6A2 INHIBITOR
Norepinephrine transporter inhibitor
KCNH1 MODULATOR
CHRM2 ANTAGONIST

Drug classes

Adrenergic Agents
Adrenergic Uptake Inhibitors
Antidepressive Agents
Antidepressive Agents, Tricyclic
Central Nervous System Agents
Membrane Transport Modulators
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Psychotropic Drugs
Tricyclic Antidepressant

ATC classes

N06A · ANTIDEPRESSANTS

Cross-references

PubChem CID: 3696
ChEMBL: CHEMBL11
DrugBank: DB00458
ChEBI: CHEBI:47499
KEGG: D00815
RxNorm: 5691
PDB: IXX
Wikipedia: Imipramine
TTD: D06ZUK
LINCS BRD: BRD-K38436528

Synonyms

Reported adverse events

Jaundice
Nausea
Orthostatic hypotension
Confusional state
Dry mouth

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