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TRIMETHOPRIM

SynDRA canonical compound SYN0000088 — structure-anchored drug synonym record

All known targets

• DHFR
• CYP2C8
• DFR1
• DHFR-TS
• SLC22A1
• SLC22A2
• TYMS
• dfrA
• dfrA17
• dhfrI
• folA

Mechanisms of action (all sources)

• dihydrofolate reductase inhibitor
• DHFR MODULATOR
• folA INHIBITOR

Drug classes

• Dihydrofolate Reductase Inhibitors
• Dihydrofolate Reductase Inhibitor Antibacterial
• Anti-Dyskinesia Agents
• Anti-Infective Agents
• Anti-Infective Agents, Urinary
• Antimalarials
• Antiparasitic Agents
• Antiprotozoal Agents
• Central Nervous System Agents
• Cytochrome P-450 CYP2C8 Inhibitors
• Cytochrome P-450 Enzyme Inhibitors
• Enzyme Inhibitors

ATC classes

• J01E · SULFONAMIDES AND TRIMETHOPRIM
• DRUGS FOR TREATMENT OF TUBERCULOSIS

Cross-references

• PubChem CID: 5578
• ChEMBL: CHEMBL22
• DrugBank: DB00440
• ChEBI: CHEBI:45924
• KEGG: D00145
• RxNorm: 10829
• PDB: TOP
• Wikipedia: Trimethoprim
• TTD: D0AO5H
• LINCS BRD: BRD-K07208025

Synonyms

• trimethoprim sulfate
• trimethoprim hydrochloride
• trimethioprim
• trimetoprim
• trimopan
• trimethoprim HCl
• Trimethoprime
• Trimetoprima
• Infectotrimet
• Trimethoprimum
• Wellcoprim
• BW-56-72
• NIH-204
• NSC-106568
• TCMDC-125538
• Ipral
• Ledatrim
• Monotrim
• Proloprim
• Proloprin
• Syraprim
• Tiempe
• Trimethoprim component of bactrim
• Trimethoprim component of bactrim ds
• Trimethoprim component of bactrim pediatric
• Trimethoprim component of co-trimoxazole
• Trimethoprim component of cotrim
• Trimethoprim component of cotrim d.s.
• Trimethoprim component of septra
• Trimethoprim component of sulfamethoprim
• Trimethoprim component of sulfatrim
• Trimethoprim component of sulmeprim
• Trimethoprim component of uroplus
• Trimogal
• Trimopan
• Trimpex
• Trimpex 200
• Triprimix 200

Reported adverse events

• Stevens-Johnson syndrome
• Agranulocytosis
• Hallucination
• Cough
• Arthralgia
• Hepatitis
• Renal failure
• Hypersensitivity
• Rash
• Pneumonia
• Thrombocytopenia
• Uveitis