SULFASALAZINE

SynDRA canonical compound SYN0000090 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	ACAT1 \| ALOX5 \| CHUK \| IKBKB \| PLA2G1B \| PPARG \| PTGS1 \| PTGS2 \| SLC46A1 \| SLC7A11 \| TBXAS1
Mechanism of action	cyclooxygenase inhibitor
Indication	ulcerative colitis
Disease area	gastroenterology

All known targets

ALOX5
PTGS2
PTGS1
ACAT1
TBXAS1
SLC7A11
SLC46A1
ABCG2
ABCB1
MMP1
SLC10A1
PPARG

Mechanisms of action (all sources)

ALOX5 INHIBITOR
Arachidonate 5-lipoxygenase inhibitor
PTGS2 INHIBITOR
Cyclooxygenase inhibitor
PTGS1 INHIBITOR
ABCG2 INHIBITOR
Activator

Drug classes

Analgesics
Analgesics, Non-Narcotic
Anti-Infective Agents
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Antirheumatic Agents
Gastrointestinal Agents
Peripheral Nervous System Agents
Sensory System Agents
Aminosalicylate

ATC classes

A07E · INTESTINAL ANTIINFLAMMATORY AGENTS

Cross-references

PubChem CID: 5339
ChEMBL: CHEMBL421
DrugBank: DB00795
ChEBI: CHEBI:9334
KEGG: D00448
PDB: SAS
TTD: D02ZTJ

Synonyms

Reported adverse events

Hypersensitivity
Guillain-Barre syndrome
Stevens-Johnson syndrome
Angioedema

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