LEVOFLOXACIN ANHYDROUS

SynDRA canonical compound SYN0000131 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	TOP2A
Mechanism of action	bacterial DNA gyrase inhibitor
Indication	anthrax \| bronchitis \| plague \| pneumonia \| prostatitis \| pyelonephritis \| sinusitis \| skin infections \| urinary tract infections
Disease area	infectious disease \| otolaryngology \| pulmonary \| urology

All known targets

Bact gyrA; Bact gyrB
KCNH2
RCE1
SLC47A1
Stap-coc parC
TOP2A
gyrA
gyrB
parC
parE

Mechanisms of action (all sources)

DNA gyrase inhibitor
Modulator
parC INHIBITOR
parE INHIBITOR
gyrB INHIBITOR
gyrA INHIBITOR

Drug classes

Quinolone Antimicrobial
Fluoroquinolone Antibacterial
Anti-Bacterial Agents
Anti-Infective Agents
Anti-Infective Agents, Urinary
Antineoplastic Agents
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Metabolic Side Effects of Drugs and Substances
Topoisomerase II Inhibitors
Topoisomerase Inhibitors

ATC classes

J01M · QUINOLONE ANTIBACTERIALS
S01A · ANTIINFECTIVES
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
COMBINATIONS OF ANTIBACTERIALS

Cross-references

PubChem CID: 149096
ChEMBL: CHEMBL33
DrugBank: DB01137
ChEBI: CHEBI:63598
KEGG: D00588
RxNorm: 1546009
PDB: LFX
Wikipedia: Levofloxacin
TTD: D02RSN
LINCS BRD: BRD-K09471561

Synonyms

Reported adverse events

Tendinitis
Peripheral neuropathy
Acute bacterial exacerbation of chronic bronchitis
Flu
TEN
STH
P
DIC
CAT
Hypersensitivity
Hepatotoxicity
Crystalluria

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