FUROSEMIDE

SynDRA canonical compound SYN0000143 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	SLC12A2
Mechanism of action	Diuretic
Indication	congestive heart failure \| edema \| hypertension \| nephrotic syndrome
Disease area	cardiology \| rheumatology

All known targets

SLC12A1
SLC12A2
GPR35
CA2
ABCG2
CA9
Hsd11b1
HSD11B1
GABRA6
Ca13
CISD1
CA7

Mechanisms of action (all sources)

Diuretic
SLC12A1 INHIBITOR
Sodium-(potassium)-chloride cotransporter 2 inhibitor
SLC12A2 INHIBITOR
GABRA6 ANTAGONIST
GPR35 AGONIST
SLC12A1 BLOCKER

Drug classes

Loop Diuretic
Diuretics
Membrane Transport Modulators
Natriuretic Agents
Sodium Potassium Chloride Symporter Inhibitors

ATC classes

C03C · HIGH-CEILING DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION

Cross-references

PubChem CID: 3440
ChEMBL: CHEMBL35
DrugBank: DB00695
ChEBI: CHEBI:47426
KEGG: D00331
RxNorm: 4603
PDB: FUN
Wikipedia: Furosemide
TTD: D0PQ3G
LINCS BRD: BRD-K78010432

Synonyms

Reported adverse events

Hypersensitivity
Orthostatic hypotension
Vomiting

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