ERGOTAMINE

SynDRA canonical compound SYN0000158 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	ADRA1A \| ADRA1B \| ADRA1D \| ADRA2A \| ADRA2B \| DRD1 \| DRD2 \| DRD5 \| HTR1A \| HTR1B \| HTR1D \| HTR1E \| HTR1F \| HTR2A \| HTR2B \| HTR2C \| HTR5A \| HTR6 \| SLC6A2
Mechanism of action	adrenergic receptor antagonist
Indication	migraine headache
Disease area	neurology/psychiatry

All known targets

ADRA1A
ADRA1D
ADRA2A
ADRA2B
HTR1D
DRD2
HTR6
HTR5A
HTR2C
HTR2B
HTR2A
HTR1F

Mechanisms of action (all sources)

HTR1D AGONIST
Serotonin 1d (5-HT1d) receptor agonist
ADRA1A AGONIST
Adrenergic receptor alpha agonist
ADRA2A AGONIST
ADRA2C AGONIST
ADRA1D AGONIST
ADRA1B AGONIST
ADRA2B AGONIST
adrenergic receptor antagonist

Drug classes

Adrenergic Agents
Adrenergic Agonists
Adrenergic alpha-1 Receptor Agonists
Adrenergic alpha-Agonists
Analgesics
Analgesics, Non-Narcotic
Cardiovascular Agents
Central Nervous System Agents
Neurotransmitter Agents
Oxytocics
Peripheral Nervous System Agents
Reproductive Control Agents

ATC classes

N02C · ANTIMIGRAINE PREPARATIONS

Cross-references

PubChem CID: 8223
ChEMBL: CHEMBL442
DrugBank: DB00696
ChEBI: CHEBI:190463
KEGG: D00679
RxNorm: 4025
PDB: ERM
Wikipedia: Ergotamine
TTD: D01TSI

Synonyms

Reported adverse events

Nausea

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