TRETINOIN

SynDRA canonical compound SYN0000162 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	ALDH1A1 \| ALDH1A2 \| GPRC5A \| NR0B1 \| NR2C2 \| PPARD \| RARA \| RARB \| RARG \| RARRES1 \| RORB \| RORC \| RXRB \| RXRG
Mechanism of action	retinoid receptor agonist \| retinoid receptor ligand
Indication	acute promyelocytic leukemia (APL)
Disease area	hematologic malignancy

All known targets

RARG
RARA
RARB
RXRG
RORC
NR2C2
RORB
PPARD
RXRB
Rxrb
Rxra
Rarg

Mechanisms of action (all sources)

RARG AGONIST
Retinoic acid receptor agonist
RARB AGONIST
RARA AGONIST
retinoid receptor agonist
retinoid receptor ligand

Drug classes

Retinoid
Antineoplastic Agents
Dermatologic Agents
Keratolytic Agents

ATC classes

D10A · ANTI-ACNE PREPARATIONS FOR TOPICAL USE
L01X · OTHER ANTINEOPLASTIC AGENTS

Cross-references

PubChem CID: 444795
ChEMBL: CHEMBL38
DrugBank: DB00755
ChEBI: CHEBI:15367
KEGG: D00094
RxNorm: 10753
PDB: 3KV
Wikipedia: Retinoic_acid
TTD: D02DGU

Synonyms

Reported adverse events

Erythema
Pruritus
Sunburn
Arrhythmia
Pain
Bone pain
Dizziness
Erythema nodosum
Flushing
Headache
Leukocytosis
Rash

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