FLUOXETINE

SynDRA canonical compound SYN0000167 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	SLC6A4
Mechanism of action	Selective serotonin reuptake inhibitor
Indication	bipolar disorder \| bulimia nervosa \| depression \| obsessive compulsive disorder (OCD) \| panic disorders
Disease area	neurology/psychiatry

All known targets

SLC6A4
HTR2B
ANO1
SLC29A4
ACHE
SCN3A
Htr6
KCNH2
KCNK2
Kcnc1
Kcnj6
NET

Mechanisms of action (all sources)

Selective serotonin reuptake inhibitor
SLC6A4 INHIBITOR
Serotonin transporter inhibitor
HTR2B ANTAGONIST
ANO1 INHIBITOR
SLC29A4 INHIBITOR
selective serotonin reuptake inhibitor (SSRI)
serotonin transporter (sert) inhibitor
SLC6A4 MODULATOR

Drug classes

Serotonin Uptake Inhibitors
Antidepressive Agents
Antidepressive Agents, Second-Generation
Central Nervous System Agents
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Membrane Transport Modulators
Metabolic Side Effects of Drugs and Substances
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Psychotropic Drugs

ATC classes

N06A · ANTIDEPRESSANTS
PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION

Cross-references

PubChem CID: 3386
ChEMBL: CHEMBL1201082
DrugBank: DB00472
ChEBI: CHEBI:5118
KEGG: D00326
RxNorm: 4493
Wikipedia: Fluoxetine
TTD: D0TR5X
LINCS BRD: BRD-A31159102

Synonyms

Reported adverse events

Suicide
Dyspepsia
Rash
Somnolence
Tremor
Dizziness
Insomnia
Nausea
Vomiting
Priapism
Asthenia
Dry mouth

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