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CLOZAPINE
SynDRA canonical compound SYN0000176 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH4 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR2A
- DRD4
- DRD2
- CHRM1
- HTR1B
- HRH4
- HTR1D
- HRH1
- HTR1E
- HTR2C
- ADRA1A
- DRD3
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR1A FULL AGONIST
- HTR1B FULL AGONIST
- HTR1D FULL AGONIST
- HTR1E FULL AGONIST
- HTR1F FULL AGONIST
- HTR2A INVERSE AGONIST
Drug classes
- Atypical Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Antagonists
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- asaleptin
- azaleptine
- clozapin
- clozaril
- fazaclo
- klozapol
- leponex
- Clozapina
- Clozapine (caraco)
- Clozapine (clozaril)
- Clozapine (fazaclo)
- Clozapine (ivax)
- Clozapine (mylan)
- Clozapine (teva)
- Clozapine (udl)
- Clozapine (versacloz)
- Leponex
- HF-1854
- NSC-757429
- Clozaril
- Fazaclo
- Fazaclo odt
- Versacloz
- Zaponex
- Clozapine resolution mixture
- Asaleptin
- CLOZARIL
- Clorazil
- Clozapin
- Clozapinum
- Iprox
- Lepotex
- Fazaclo ODT
- C 6305
- HF1854
- Clopine (TN)
- Clozapina [INN-Spanish]
- Clozapine(tautomer)
Reported adverse events
- Cardiomyopathy
- Hypotension
- Seizure
- Syncope
- Myocarditis
- Neutropenia
- Orthostatic hypotension
- Bradycardia
- Seizures
- TIA
- Pericarditis
- ECG
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