GEMFIBROZIL

SynDRA canonical compound SYN0000230 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	PPARA
Mechanism of action	Lipoprotein lipase activator
Indication	coronary heart disease \| hyperlipidemia
Disease area	cardiology \| endocrinology

All known targets

PPARA
LPL
CYP2C8
SLCO1B1
SLCO1B3
SLCO2B1
CISD1
CYP2C9
Fabp1
PPARG
TTR

Mechanisms of action (all sources)

Lipoprotein lipase activator
PPARA AGONIST
Peroxisome proliferator-activated receptor alpha agonist
SLCO1B1 INHIBITOR
SLCO1B3 INHIBITOR
SLCO2B1 INHIBITOR
LPL ACTIVATOR

Drug classes

Peroxisome Proliferator-activated Receptor alpha Agonists
Peroxisome Proliferator Receptor alpha Agonist
Antimetabolites
Cytochrome P-450 CYP2C8 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Hypolipidemic Agents
Lipid Regulating Agents
Metabolic Side Effects of Drugs and Substances

ATC classes

C10A · LIPID MODIFYING AGENTS, PLAIN

Cross-references

PubChem CID: 3463
ChEMBL: CHEMBL457
DrugBank: DB01241
ChEBI: CHEBI:5296
KEGG: D00334
RxNorm: 4719
PDB: 4TX
Wikipedia: Gemfibrozil
TTD: D05VIX
LINCS BRD: BRD-K11129031

Synonyms

Reported adverse events

Dyspepsia
Eczema
Fatigue
Vertigo
Constipation
Headache
Nausea
Rash
Vomiting
Lupus-like syndrome
Atrial fibrillation
Somnolence

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