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THALIDOMIDE
SynDRA canonical compound SYN0000329 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TNF |
|---|
| Mechanism of action | TNF production inhibitor |
|---|
| Indication | myeloma |
|---|
| Disease area | oncology |
|---|
All known targets
- CRBN
- TNF
- CUL4A
- CYP1A2
- CYP2B6
- CYP2C19
- CYP3A5
- DDB1
- PTGS1
- PTGS2
- RBX1
Mechanisms of action (all sources)
- TNF production inhibitor
- CRBN INHIBITOR
- CRL4(CRBN) E3 ubiquitin ligase inhibitor
- DDB1 INHIBITOR
- CUL4A INHIBITOR
- RBX1 INHIBITOR
- CRBN BINDER
- tumor necrosis factor production inhibitor
- TNF INHIBITOR
- CRBN MODULATOR
Drug classes
- Angiogenesis Inhibitors
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antineoplastic Agents
- Growth Inhibitors
- Growth Substances
- Immunologic Factors
- Immunosuppressive Agents
- Leprostatic Agents
- Noxae
- Teratogens
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- (+/-)-Thalidomide
- thalomid
- Talidomida
- .alpha.-phthalimidoglutarimide
- Celgene
- Contergan
- Distaval
- Myrin
- N-phthalylglutamic acid imide
- Neurosedyn
- Pantosediv
- Pharmion
- Softenon
- Thaled
- K-17
- NSC-527179
- NSC-66847
- Kevadon
- Talidex
- Thalidomide bms (previously thalidomide celgene)
- Thalidomide lipomed
- Thalomid
- Algosediv
- Asmadion
- Asmaval
- Bonbrain
- Bonbrrin
- Calmore
- Calmorex
- Corronarobetin
- Distaxal
- Distoval
- Ectiluran
- Enterosediv
- Gastrinide
- Glupan
- Glutanon
- Grippex
Reported adverse events
- DVT
- Asthenia
- Atrial fibrillation
- Bradycardia
- Confusional state
- Constipation
- Depression
- Dizziness
- Dry mouth
- Dry skin
- Leukopenia
- Malaise
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