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DOFETILIDE

SynDRA canonical compound SYN0000366 — structure-anchored drug synonym record

All known targets

• KCNH2
• KCNH1
• KCNK2
• KCNJ12

Mechanisms of action (all sources)

• Potassium channel blocker
• KCNH2 BLOCKER
• HERG blocker
• KCNH1 MODULATOR
• KCNH2 INHIBITOR

Drug classes

• Antiarrhythmic
• Anti-Arrhythmia Agents
• Cardiovascular Agents
• Membrane Transport Modulators
• Potassium Channel Blockers

ATC classes

• C01B · ANTIARRHYTHMICS, CLASS I AND III

Cross-references

• PubChem CID: 71329
• ChEMBL: CHEMBL473
• DrugBank: DB00204
• ChEBI: CHEBI:4681
• KEGG: D00647
• RxNorm: 49247
• Wikipedia: Dofetilide
• TTD: D0NW3X
• LINCS BRD: BRD-K86887724

Synonyms

• UK 68798
• tikosyn
• UK-68,798
• Dofetilida
• UK-68798
• Tikosyn
• Dofetilidum
• Xelide
• Dofetilida [INN-Spanish]
• Dofetilidum [INN-Latin];Tikosyn (TN)
• Dofetilide [USAN:BAN:INN]
• Tikosyn, UK68798, Dofetilide
• Dofetilide (JAN/USAN/INN)
• Beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
• N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
• N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
• Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)
• 1-(4-methanesulfonamidophenoxy)-2-(N-(4-methanesulfonamidophenethyl)-N-methylamine)ethane
• 1-MSPMPE
• Dofetilidum [INN-Latin]
• UK 68,798
• C19H27N3O5S2
• N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
• Dofetilide (Tikosyn)
• beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
• CHEMBL473
• R4Z9X1N2ND
• CHEBI:4681
• 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
• N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
• Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
• NCGC00164549-01
• UK 68789
• Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-
• SMR000466333
• Tikosyn (TN)
• CAS-115256-11-6
• UNII-R4Z9X1N2ND

Reported adverse events

• Arrhythmia
• Ventricular fibrillation
• Ventricular tachycardia
• Bundle branch block