CHLORPROMAZINE

SynDRA canonical compound SYN0000402 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	ADRA1A \| ADRA1B \| ADRA1D \| ADRA2A \| ADRA2B \| ADRA2C \| CALM1 \| CHRM1 \| CHRM3 \| DRD1 \| DRD2 \| DRD3 \| DRD4 \| DRD5 \| HRH1 \| HRH4 \| HTR1A \| HTR2A \| HTR2B \| HTR2C \| HTR6 \| HTR7 \| KCNH2 \| KIF11 \| ORM1 \| ORM2 \| SMPD1 \| TRPC5
Mechanism of action	dopamine receptor antagonist
Indication	acute intermittent porphyria (AIP) \| nausea \| schizophrenia \| tetanus \| vomiting
Disease area	gastroenterology \| hematology \| infectious disease \| neurology/psychiatry

All known targets

DRD2
HTR2A
DRD4
DRD3
HRH1
DRD1
HTR7
HTR6
HTR2C
DRD5
ADRA2C
ADRA2A

Mechanisms of action (all sources)

HTR2A ANTAGONIST
Serotonin 2a (5-HT2a) receptor antagonist
DRD2 ANTAGONIST
D2-like dopamine receptor antagonist
DRD3 ANTAGONIST
DRD4 ANTAGONIST
HTR1A ANTAGONIST
HTR2A INVERSE AGONIST
HTR2C ANTAGONIST
HTR6 INVERSE AGONIST
HTR7 INVERSE AGONIST
ADRA2A ANTAGONIST

Drug classes

Antiemetics
Antipsychotic Agents
Central Nervous System Agents
Central Nervous System Depressants
Dopamine Agents
Dopamine Antagonists
Gastrointestinal Agents
Neurotransmitter Agents
Peripheral Nervous System Agents
Psychotropic Drugs
Tranquilizing Agents
Phenothiazine

ATC classes

N05A · ANTIPSYCHOTICS

Cross-references

PubChem CID: 2726
ChEMBL: CHEMBL71
DrugBank: DB00477
ChEBI: CHEBI:3647
KEGG: D00270
RxNorm: 2403
PDB: Z80
Wikipedia: Chlorpromazine
TTD: D01ZII
LINCS BRD: BRD-K89997465

Synonyms

Reported adverse events

Dyskinesia
Sudden death
Agranulocytosis
Dystonia
Hyperpyrexia
Jaundice
Psychotic symptom

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