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NALOXONE
SynDRA canonical compound SYN0000435 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | OPRM1 |
|---|
| Mechanism of action | Opioid receptor antagonist |
|---|
| Indication | respiratory depression |
|---|
| Disease area | pulmonary |
|---|
All known targets
- OPRM1
- OPRD1
- OPRK1
- ADORA3
- CREB1
- CYP2D6
- Ccr5
- ESR1
- Oprd1
- Oprk1
- Oprm1
- Sigmar1
Mechanisms of action (all sources)
- Opioid receptor antagonist
- OPRK1 ANTAGONIST
- Opioid receptors; mu/kappa/delta antagonist
- OPRD1 ANTAGONIST
- OPRM1 ANTAGONIST
Drug classes
- Opioid Antagonists
- Central Nervous System Agents
- Narcotic Antagonists
- Peripheral Nervous System Agents
- Sensory System Agents
- Opioid Antagonist
ATC classes
- A06A · DRUGS FOR CONSTIPATION
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
- OPIOIDS
Cross-references
Synonyms
- naloxone hydrochloride dihydrate
- naloxone hydrochloride hydrate
- naloxone hydrobromide
- evzio
- l-naloxone
- (-)-Naloxone
- naloxone hydrochloride
- naloxone HCl
- Naloxona
- Dbl naloxone
- NSC-70413
- Nalone
- Nalossone
- Naloxonum
- Narcan
- Narcanti
- Narcon
- DBL Naloxone
- Nalossone [DCIT]
- Naloxone HCl
- EN 1530base
- DBL Naloxone (TN)
- L-Naloxone
- N-Allylnoroxymorphone
- Nalone (TN)
- Naloxona [INN-Spanish]
- Naloxone (INN)
- Naloxone [INN:BAN]
- Naloxonum [INN-Latin]
- Narcan (TN)
- Narcanti (TN)
- N-Allyl-noroxymorphone
- L-N-Allyl-14-hydroxynordihydromorphinone
- L-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
- N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon
- Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-(8CI)
- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-(9CI)
- (-)-N-allyl-14-hydroxynordihydroxymorphinan-6-one
Reported adverse events
- NGS
- Addiction
- Hypotension
- Nausea
- Dizziness
- Vomiting
- Depression
- Headache
- Anxiety
- Chills
- Cough
- Dyspepsia
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