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RALOXIFENE
SynDRA canonical compound SYN0000436 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ESR2 |
|---|
| Mechanism of action | Selective estrogen receptor modulator |
|---|
| Indication | breast cancer | osteoporosis |
|---|
| Disease area | oncology | orthopedics |
|---|
All known targets
- ESR1
- ESR2
- GPER1
- AOX1
- NR1I2
- HTR2B
- HTR2C
- HTR6
- Htr1b
- IL6
- KDM1A
- NR1H4
Mechanisms of action (all sources)
- ESR1 ANTAGONIST
- Selective estrogen receptor modulator
- ESR2 MODULATOR
- ESR1 MODULATOR
- AOX1 INHIBITOR
- ESR1 AGONIST
- ESR2 ANTAGONIST
- GPER1 FULL AGONIST
- selective estrogen receptor modulator (SERM)
Drug classes
- Selective Estrogen Receptor Modulators
- Estrogen Agonist/Antagonist
- Bone Density Conservation Agents
- Estrogen Antagonists
- Estrogen Receptor Modulators
- Hormone Antagonists
ATC classes
- G03X · OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Cross-references
Synonyms
- keoxifene
- raloxifene hydrochloride
- evista
- raloxifene HCl
- Raloxifeno
- Eviden
- Keoxifene
- Raloxiphene
- Raxeto
- J22.982B
- LY-139481
- NSC-747974
- Raloxifene (extended-release, CDT)
- Raloxifenum
- Raloxifenum [Latin]
- Raloxifeno [Spanish]
- Pharoxifene
- CHEMBL81
- (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone
- NSC 747974
- (2-(4-Hydroxyphenyl)-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone
- [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
- Keoxifene; LY 139481;
- CHEBI:8772
- YX9162EO3I
- Raloxifene (INN)
- 2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol
- Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-
- LY139481
- RALOXIFENE [INN]
- Raloxifene [INN:BAN]
- 2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
- Methanone, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
- CCRIS 7129
- HSDB 7460
- NCGC00015889-05
- CAS-82640-04-8
- UNII-YX9162EO3I
Reported adverse events
- K
- Headache
- Rash
- Nausea
- Arthralgia
- Arthritis
- Bronchitis
- Conjunctivitis
- Cough
- Cystitis
- Depression
- Dyspepsia
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