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TOPOTECAN
SynDRA canonical compound SYN0000450 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TOP1 |
|---|
| Mechanism of action | Topoisomerase inhibitor |
|---|
| Indication | cervical cancer | small cell lung cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TOP1
- TOP1MT
- ABCB1
- ABCC2
- ABCC4
- ABCG2
- CYP3A4
- HIF1A
- NR1I2
- SLC22A2
- SLC47A1
- SLC47A2
Mechanisms of action (all sources)
- topoisomerase inhibitor
- TOP1 INHIBITOR
- DNA topoisomerase I inhibitor
- TOP1 MODULATOR
- TOP1MT INHIBITOR
Drug classes
- Topoisomerase Inhibitors
- Topoisomerase Inhibitor
- Antineoplastic Agents
- Enzyme Inhibitors
- Topoisomerase I Inhibitors
ATC classes
- L01C · PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- nogitecan
- potactasol
- nogitecan hydrochloride
- (S)-Topotecan
- hycamptamine
- topotecan lactone
- topotecan hydrochloride
- hycamtin
- nogitecan HCl
- topotecan HCl
- Topotecane
- Ff-10850 (liposomal topotecan)
- Hycamptamine
- Hycamptin
- Nogitecan
- NSC-609699
- NSC-641007
- SK&F-104864
- SKF-104864
- Hycamtamine
- Topotecanum
- Topotecan lactone
- SKF 104864
- SKF-S 104864
- TOPOTECAN, HYCAMTIN
- Topotecan (BAN)
- Topotecan [INN:BAN]
- Topotecane [INN-French]
- Topotecanum [INN-Latin]
- Topotecan Monohydrochloride, (S)-Isomer
- (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
- (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE
- (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
- (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 9-Dimethylaminomethyl-10-hydroxycamptothecin
- Topetecan
- TOPOTECAN HYDROCHLORIDE
Reported adverse events
- Fatigue
- Neutropenia
- Thrombocytopenia
- Infection
- Hypersensitivity
- Interstitial lung disease
- Nausea
- Sepsis
- Extravasation
- Asthenia
- Febrile neutropenia
- Vomiting
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