IBUPROFEN

SynDRA canonical compound SYN0000618 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	PTGS2
Mechanism of action	Cyclooxygenase inhibitor
Indication	backache \| common cold \| fever \| headache \| menstrual pain \| muscle pain \| rheumatoid arthritis \| toothache
Disease area	dental \| endocrinology \| neurology/psychiatry \| obstetrics/gynecology \| otolaryngology \| rheumatology

All known targets

PTGS2
PTGS1
SLC5A8
ASIC1
CXCL8
AKR1C2
Slc22a20
SLC36A1
Ptgs2
Ptgs1
Ptgds
Dhrs9

Mechanisms of action (all sources)

Cyclooxygenase inhibitor
PTGS2 INHIBITOR
PTGS1 INHIBITOR
ASIC1 MODULATOR
SLC36A1 INHIBITOR
SLC5A8 INHIBITOR
CXCR1 INHIBITOR
CXCR2 INHIBITOR
CXCL8 INHIBITOR

Drug classes

Cyclooxygenase Inhibitors
Analgesics
Analgesics, Non-Narcotic
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Antirheumatic Agents
Central Nervous System Agents
Enzyme Inhibitors
Peripheral Nervous System Agents
Sensory System Agents
Nonsteroidal Anti-inflammatory Drug

ATC classes

G02C · OTHER GYNECOLOGICALS
M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
R02A · THROAT PREPARATIONS
C01E · OTHER CARDIAC PREPARATIONS
OPIOIDS

Cross-references

PubChem CID: 3672
ChEMBL: CHEMBL427526
DrugBank: DB01050
ChEBI: CHEBI:132922
KEGG: D00126
RxNorm: 5640
Wikipedia: Ibuprofen
TTD: D0R1QE
LINCS BRD: BRD-A17655518

Synonyms

Reported adverse events

Bleeding
GI bleed
Ulceration
Perforation
Elderly
Addiction
NGS
Nausea
Rash
Depression
Dizziness
Dry eye

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