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CLOTRIMAZOLE
SynDRA canonical compound SYN0000731 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
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| Primary target(s) | KCNN4 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | oropharyngeal candidiasis | vulvovaginal candidiasis |
|---|
| Disease area | infectious disease |
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All known targets
- KCNN4
- NR1I3
- NR1I2
- TRPM2
- CYP3A4
- CYP51A1
- TRPM8
- TRPM4
- ABCB1
- KCNMA1
- NR1H4
- MDH1
Mechanisms of action (all sources)
- Imidazoline ligand
- Cytochrome P450 inhibitor
- NR1I3 ANTAGONIST
- KCNMA1 MODULATOR
- KCNN4 INHIBITOR
- NR1I2 AGONIST
- TRPM2 ANTAGONIST
- TRPM4 ANTAGONIST
- TRPM8 MODULATOR
- imidazoline receptor ligand
- CXCR2 MODULATOR
- ERG11 INHIBITOR
Drug classes
- Azole Antifungal
- 14-alpha Demethylase Inhibitors
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antifungal Agents
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Hormone Antagonists
- Metabolic Side Effects of Drugs and Substances
- Steroid Synthesis Inhibitors
ATC classes
- A01A · STOMATOLOGICAL PREPARATIONS
- G01A · ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- D01A · ANTIFUNGALS FOR TOPICAL USE
Cross-references
Synonyms
- lotrimin
- rimazole
- locasten
- Clotrimazol
- Lotrimin
- SVT-15652
- Trivagizole
- BAY-5097
- GNF-PF-3499
- NSC-257473
- Abtrim
- Actavall
- Candiden
- Canesten
- Canesten af
- Canesten crm combi
- Canesten internal
- Canesten vc
- Clotrimazole component of lotrisone
- Fungederm
- Gyne-lotrimin
- Gyne-lotrimin 3
- Gyne-lotrimin 3 combination pack
- Gyne-lotrimin combination pack
- Gynix
- Masnoderm
- Mycelex
- Mycelex-7
- Mycelex-7 combination pack
- Mycelex-g
- Mycil gold
- Privacom
- Trimysten
- Trivagizole 3
- Canestene
- Canestine
- Canifug
- Chlotrimazole
Reported adverse events
- Cushing's syndrome
- Nausea
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