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ERLOTINIB

SynDRA canonical compound SYN0000783 — structure-anchored drug synonym record

All known targets

• EGFR
• SLCO2B1
• AAK1
• PLK4
• PIP4K2C
• PDGFRB
• PDGFRA
• NR1I2
• MYLK2
• MKNK2
• MKNK1
• MINK1

Mechanisms of action (all sources)

• EGFR INHIBITOR
• Epidermal growth factor receptor erbB1 inhibitor
• SLCO2B1 INHIBITOR

Drug classes

• Protein Kinase Inhibitors
• Antineoplastic Agents
• Enzyme Inhibitors
• Kinase Inhibitor
• Tyrosine Kinase Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 176870
• ChEMBL: CHEMBL553
• DrugBank: DB00530
• ChEBI: CHEBI:114785
• KEGG: D04023
• RxNorm: 337525
• PDB: AQ4
• Wikipedia: Erlotinib
• TTD: D07POC
• LINCS BRD: BRD-K70401845

Synonyms

• erlotinib hydrochloride
• tarceva
• CP-358,774-01
• OSI-774
• erlotinib HCl
• CP-358,774
• CP-358774
• CP-35877401
• R-1415
• RG-1415
• Ro-508231
• Erlotinin
• Tarceva
• Erlotinib Base
• OSI 744
• R 1415
• Erlotinib(Tarceva)
• Tarceva (TN)
• Erlotinib, OS-774
• N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine
• N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
• N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
• [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE
• [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine
• 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
• Erlotinib free base
• 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-
• Erlotinib, Free Base
• 183321-74-6 (free base)
• NSC 718781
• CHEMBL553
• J4T82NDH7E
• CP358774
• CHEBI:114785
• MFCD02089651
• NCGC00164574-01
• CAS-183321-74-6
• NSC718781

Reported adverse events

• Rash
• Hepatic failure
• Infection
• Nausea
• Stevens-Johnson syndrome
• Conjunctivitis
• Cough
• Dry skin
• Fatigue
• Headache
• Pruritus
• Pyrexia