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LAPATINIB
SynDRA canonical compound SYN0000785 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
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| Primary target(s) | ERBB2 |
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| Mechanism of action | ErbB2 inhibitor |
|---|
| Indication | breast cancer |
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| Disease area | oncology |
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All known targets
- EGFR
- ERBB2
- ABCB1
- MAP2K7
- STK10
- SLK
- SLCO1B1
- RIPK2
- PIK3C2G
- PIK3C2B
- PI4KB
- PDGFRB
Mechanisms of action (all sources)
- EGFR INHIBITOR
- ERBB2 INHIBITOR
- Receptor protein-tyrosine kinase erbB-2 inhibitor
- Epidermal growth factor receptor erbB1 inhibitor
- EEF2K INHIBITOR
Drug classes
- Protein Kinase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Kinase Inhibitor
- Tyrosine Kinase Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- lapatinib tosilate hydrate
- lapatinib tosilate
- GW 572016X
- tyverb
- lapatinib ditosylate
- GW572016F
- lapatinib ditosilate
- lapatinib ditosilate hydrate
- lapatinib ditosylate hydrate
- FMM
- GSK-572016
- GSK572016
- GW-2016
- GW-572016
- GW-572016X
- GW2016
- GW572016
- LAPATANIB
- LAPATINIB (FREE BASE)
- LAPATINIB (GW-572016)
- Lapatinib ditosylate
- Lapatinib ditosylate monohydrate
- Tykerb
- Tyverb
- Tycerb
- Lapatinib Ditosylate
- Lapatinib [INN]
- Lapatinib tosilate hydrate
- GSK 572016
- GW 572016
- Lapatinib (INN)
- Tykerb (TN)
- Lapatinib, Tykerb, GW572016
- N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
- N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
- N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
- N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
- 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
Reported adverse events
- Hepatotoxicity
- Epistaxis
- Fatigue
- Headache
- Hypersensitivity
- Insomnia
- Nail disorder
- Pain
- Pain in extremity
- Rash
- Ventricular arrhythmia
- Alopecia
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