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LOFEXIDINE
SynDRA canonical compound SYN0001045 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2A |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | opioid withdrawal |
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| Disease area | neurology/psychiatry |
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All known targets
- ADRA2A
- ADRA2B
- ADRA2C
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
- Adra2c
- HTR1A
- Nisch
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA2A AGONIST
- Adrenergic receptor alpha-2 agonist
- ADRA2C AGONIST
- ADRA2B AGONIST
Drug classes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Antihypertensive Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Narcotic Antagonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- N07B · DRUGS USED IN ADDICTIVE DISORDERS
Cross-references
Synonyms
- lofexidine hydrochloride
- (+/-)-Lofexidine
- lofexidine HCl
- lofexadine
- Lofexidina
- Britlofex
- Lofexidinum
- Britlofex (TN)
- Lofexidina [INN-Spanish]
- Lofexidine (INN)
- Lofexidine [INN:BAN]
- Lofexidinum [INN-Latin]
- 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-(9CI)
- 2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole
- 2-(a-(2,6-dichlorophenoxy)ethyl)2-imidazoline
- 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline
- 2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline
- 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
- 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole
- 1H-Imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-
- 2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-2-IMIDAZOLINE
- UI82K0T627
- 1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-
- 2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline
- DTXCID703221
- CHEBI:51368
- RefChem:58519
- N07BC04
- Lofexidine (hydrochloride)
- Baq-168;MDL-14042
- Lucemyra
- LOFEXIDINE [INN]
- SR-01000763628
- UNII-UI82K0T627
- (+)-Lofexidine; (S)-(+)-Lofexidine
- LOFEXIDINE [MI]
- LOFEXIDINE [VANDF]
- LOFEXIDINE [WHO-DD]
Reported adverse events
- Bradycardia
- Dizziness
- Hypotension
- Insomnia
- Orthostatic hypotension
- Sedation
- Somnolence
- Syncope
- Tinnitus
- Depression
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