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AMITRIPTYLINE
SynDRA canonical compound SYN0001267 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Norepinephrine reuptake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A4
- SLC6A2
- CHRM1
- HTR6
- CHRM5
- CHRM4
- CHRM3
- CHRM2
- HRH1
- ADRA1A
- ADRA1D
- NTRK1
Mechanisms of action (all sources)
- Norepinephrine inhibitor
- Serotonin reuptake inhibitor
- Serotonin receptor antagonist
- Norepinephrine reuptake inhibitor
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- HTR6 ANTAGONIST
- ADRA1A ANTAGONIST
- HRH1 ANTAGONIST
- LPAR1 ANTAGONIST
Drug classes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Peripheral Nervous System Agents
- Psychotropic Drugs
ATC classes
- N06A · ANTIDEPRESSANTS
- PSYCHOLEPTICS AND PSYCHOANALEPTICS IN COMBINATION
Cross-references
Synonyms
- amitriprolidine
- amitriptylin
- damitriptyline
- amitriptyline hydrochloride
- amitryptiline
- amitryptiline hydrochloride
- amitriptyline HCl
- amitryptiline HCl
- Amitriptilina
- Damitriptyline
- Flavyl
- Laroxyl
- Proheptadiene
- Seroten
- Triptanol
- Adepress
- Adepril
- Amitril
- Amitriprolidine
- Amitriptylin
- Amitriptylinum
- Amitryptiline
- Amitryptyline
- Amytriptiline
- Amytriptylin
- Damilan
- Damilen
- Elanil
- Elavil
- Lantron
- Laroxil
- Redomex
- Sarotex
- Sylvemid
- Triptilin
- Triptisol
- Tryptanol
- Amitriptilina [Italian]
Reported adverse events
- Alopecia
- Myocardial infarction
- Testicular swelling
- Coma
- Hepatic failure
- Lupus-like syndrome
- Akathisia
- Nausea
- Hypotension
- Anaphylactoid reaction
- Dyskinesia
- Dystonia
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