PROMETHAZINE

SynDRA canonical compound SYN0001290 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	HRH1
Mechanism of action	Histamine receptor antagonist
Indication	allergic rhinitis \| sedative
Disease area	allergy \| neurology/psychiatry

All known targets

HRH1
ADRA1A
DRD3
HRH2
HRH4
HTR1A
HTR2A
HTR2B
HTR2C
HTR6
Htr1a
PDR5

Mechanisms of action (all sources)

Histamine receptor antagonist
HRH1 ANTAGONIST
Histamine H1 receptor antagonist

Drug classes

Anti-Allergic Agents
Antipruritics
Dermatologic Agents
Histamine Agents
Histamine Antagonists
Histamine H1 Antagonists
Neurotransmitter Agents
Phenothiazine

ATC classes

R06A · ANTIHISTAMINES FOR SYSTEMIC USE
D04A · ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ALL OTHER THERAPEUTIC PRODUCTS

Cross-references

PubChem CID: 4927
ChEMBL: CHEMBL1200750
DrugBank: DB01069
ChEBI: CHEBI:8461
KEGG: D00480
RxNorm: 8745
Wikipedia: Promethazine
TTD: D0T2XU
LINCS BRD: BRD-A46335897

Synonyms

Reported adverse events

Respiratory depression
Depression
Death
P
ECT
Sedation
Leukopenia
Dry mouth
Hallucination
Neuroleptic malignant syndrome
Asthma
Dermatitis

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