PREDNISOLONE

SynDRA canonical compound SYN0001291 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	NR3C1 \| NR3C2 \| SERPINA6
Mechanism of action	glucocorticoid receptor agonist
Indication	conjunctivitis \| cyclitis \| iritis \| punctate keratitis \| rosacea \| shingles
Disease area	dermatology \| infectious disease \| ophthalmology

All known targets

NR3C1
NR3C2
SERPINA6
ADAM17
ANXA1
AR
Fabp1
GLUL
GPBAR1
IL6
PGR

Mechanisms of action (all sources)

NR3C1 AGONIST
NR3C1 MODULATOR

Drug classes

Corticosteroid Hormone Receptor Agonists
Corticosteroid
Hormones
Anti-Inflammatory Agents
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Glucocorticoids

ATC classes

S02B · CORTICOSTEROIDS
D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
A01A · STOMATOLOGICAL PREPARATIONS
D07A · CORTICOSTEROIDS, PLAIN
C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
S01B · ANTIINFLAMMATORY AGENTS
S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS

Cross-references

PubChem CID: 5755
ChEMBL: CHEMBL131
DrugBank: DB00860
ChEBI: CHEBI:8378
KEGG: D00472
RxNorm: 8638
PDB: TUA
Wikipedia: Prednisolone
TTD: D0D1SG

Synonyms

Reported adverse events

Exophthalmos
Cushingoid
Increased appetite
Hypertrophic cardiomyopathy
Hypertension
Fluid retention
Sodium retention
Petechiae
Vertigo
Osteoporosis
Pancreatitis
Bradycardia

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