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DICLOFENAC
SynDRA canonical compound SYN0001394 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | migraine headache | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | neurology/psychiatry | rheumatology |
|---|
All known targets
- PTGS1
- PTGS2
- ASIC3
- PPARG
- TRPM3
- AKR1C3
- UGT1A7
- UGT1A6
- UGT1A10
- UGT1A1
- TTR
- TRPA1
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- ASIC3 MODULATOR
- PPARG ANTAGONIST
- SLC36A1 INHIBITOR
- TRPM3 MODULATOR
- Modulator
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Enzyme Inhibitors
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- S01B · ANTIINFLAMMATORY AGENTS
- D11A · OTHER DERMATOLOGICAL PREPARATIONS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Cross-references
Synonyms
- diclofenac calcium
- diclofenac diethylamine
- diclofenac hydroxyethylpyrrolidine
- diclofenamic acid
- diclofenac sodium
- diclofenac potassium
- diclofenac epolamine
- Diclofenaco
- Arthrotec
- Diclofenac acid
- Diclofenac free acid
- LAS41007
- LAS-41007
- Voltaren ophthalmic
- Voltaren-xr
- Zorvolex
- Zorvolex capsules
- Dermatological agent (topical, actinic keratosis), Almirall
- Diclofenac (sodium matrix patch, pain)
- (2-((2,6-DICHLOROPHENYL)AMINO)PHENYL)ACETIC ACID
- (O-(2,6-DICHLOROANILINO)PHENYL)ACETIC ACID
- aceclofenac impurity a (ep impurity)
- Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-
- 2-(2-((2,6-Dichlorophenyl)amino)phenyl)acetic acid
- Diclophenac
- Diclofenacum
- Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-
- 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
- Allvoran
- CHEBI:47381
- [2-(2,6-Dichloroanilino)phenyl]acetic acid
- {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
- Dicrofenac
- (2-(2,6-dichloroanilino)phenyl)acetic acid
- 2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid
- Xiclo
- Voltaren-XR
- RefChem:6419
Reported adverse events
- GI bleed
- Bleeding
- Hepatotoxicity
- Ulceration
- Perforation
- Elderly
- Ulcer
- Abortion
- Uterine rupture
- P
- Teratogenicity
- Hypertension
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