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MEMANTINE

SynDRA canonical compound SYN0001957 — structure-anchored drug synonym record

All known targets

• GRIN1
• ACHE
• CD4
• CD8A; CD8B
• CYP2E1
• GRIN2A
• GRIN2B
• GRIN3A
• Grin2c
• HTR3A
• SLC22A1

Mechanisms of action (all sources)

• Glutamate receptor antagonist
• GRIN3A NEGATIVE ALLOSTERIC MODULATOR
• GRIN1 NEGATIVE ALLOSTERIC MODULATOR
• GRIN2B NEGATIVE ALLOSTERIC MODULATOR
• GRIN2A NEGATIVE ALLOSTERIC MODULATOR

Drug classes

• NMDA Receptor Antagonists
• Anti-Dyskinesia Agents
• Antiparkinson Agents
• Central Nervous System Agents
• Dopamine Agents
• Excitatory Amino Acid Antagonists
• Neurotransmitter Agents
• N-methyl-D-aspartate Receptor Antagonist

ATC classes

• N06D · ANTI-DEMENTIA DRUGS

Cross-references

• PubChem CID: 4054
• ChEMBL: CHEMBL1699
• DrugBank: DB01043
• ChEBI: CHEBI:64312
• KEGG: D04905
• RxNorm: 6719
• Wikipedia: Memantine
• TTD: D01JEU
• LINCS BRD: BRD-A79803969

Synonyms

• alzantin
• memantina
• memantine hydrochloride
• ebixa
• namenda
• maruxa
• memantine HCl
• nemdatine
• Memantina
• D-145
• DRG-0267
• NSC-757843
• Memantine ER
• Namenda XR
• Memantine (extended release)
• Memantine (extended release), Forest
• W8O17SJF3T
• 3,5-DIMETHYLTRICYCLO(3.3.1.1(SUP 3,7))DECAN-1-AMINE
• TRICYCLO(3.3.1.1(SUP 3,7))DECAN-1-AMINE, 3,5-DIMETHYL-
• 3,5-Dimethyl-1-adamantanamine
• NSC 757843
• D 145
• 1-Amino-3,5-dimethyladamantane
• DRG 0267
• 3,5-dimethyladamantan-1-amine
• Memantinum
• 1,3-Dimethyl-5-adamantanamine
• 3,5-Dimethyl-1-aminoadamantane
• Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-
• 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
• 1,3-Dimethyl-5-aminoadamantane
• DTXCID3025174
• CHEBI:64312
• Tricyclo(3.3.1.13,7)decan-1-amine, 3,5-dimethyl-
• Memantin
• N06DX01
• RefChem:5992
• D145

Reported adverse events

• Hallucination
• Somnolence
• Constipation
• Headache
• Vomiting
• Dizziness
• Hypertension
• Seizure
• Fatigue
• Cough
• Back pain
• Parkinsonism