TOLAZAMIDE

SynDRA canonical compound SYN0002025 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · OTC
Primary target(s)	ABCC8 \| KCNJ1 \| KCNJ10 \| KCNJ11
Mechanism of action	ATP channel blocker
Indication	diabetes mellitus
Disease area	endocrinology

All known targets

ABCC8
KCNJ11
KCNJ10
ALOX15
KCNJ1

Mechanisms of action (all sources)

KCNJ11 BLOCKER
Sulfonylurea receptor 1, Kir6.2 blocker
ABCC8 BLOCKER
ATP channel blocker
KCNJ10 BLOCKER

Drug classes

Sulfonylurea
Hypoglycemic Agents

ATC classes

A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS

Cross-references

PubChem CID: 5503
ChEMBL: CHEMBL817
DrugBank: DB00839
ChEBI: CHEBI:9613
KEGG: D00379
Wikipedia: Tolazamide
TTD: D09FJB
LINCS BRD: BRD-K32164935

Synonyms

norglycin
tolanase
tolinase
Tolazamida
NSC-70762
U-17835
Tolinase
Diabewas
Norglycin
Tolamide
Tolanase
Tolazamidum
Tolazolamide
Pharmacia Brand of Tolazamide
T 2408
Tolazamida [INN-Spanish]
Tolazamidum [INN-Latin]
Tolinase (TN)
Tolazamide (JP15/USP/INN)
Tolazamide [USAN:INN:BAN:JAN]
N-(p-Toluenesulfonyl)-N'-hexamethyleniminourea
N-[(azepan-1-ylamino)carbonyl]-4-methylbenzenesulfonamide
N-(((hexahydro-1H-azepin-1-yl)amino)carbonyl)-4-methylbenzenesulfonamide
Benzenesulfonamide, {N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-}
N-(((Hexahydro-1H-azepin-1-yl)-amino)carbonyl)-4-methylbenzenesulfonamide
1-(((((4-Methylphenyl)sulfonyl)amino)carbonyl)amino)azepane
1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea
1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea
1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
3-azepan-1-yl-1-(4-methylphenyl)sulfonyl-urea
4-(p-Tolylsulfonyl)-1,1-hexamethylene
4-(p-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide
59866P
NSC 70762
U 17835
NCI-C03327
CCRIS 591

Reported adverse events

Leukopenia
Porphyria

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