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BOSUTINIB
SynDRA canonical compound SYN0002147 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | CAMK2G |
|---|
| Mechanism of action | Abl kinase inhibitor |
|---|
| Indication | chronic myeloid leukemia (CML) |
|---|
| Disease area | hematologic malignancy |
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All known targets
- ABL1
- SRC
- LYN
- HCK
- CAMK2G
- STK10
- TNK2
- CAMK1D
- STK24
- TXK
- MAP4K5
- BCR
Mechanisms of action (all sources)
- SRC inhibitor
- Abl kinase inhibitor
- ABL1 INHIBITOR
- Tyrosine-protein kinase ABL inhibitor
- Tyrosine-protein kinase SRC inhibitor
- HCK INHIBITOR
- Tyrosine-protein kinase HCK inhibitor
- LYN INHIBITOR
- Tyrosine-protein kinase Lyn inhibitor
- CAMK1D INHIBITOR
- CAMK2G INHIBITOR
- FYN INHIBITOR
Drug classes
- Bcr-Abl Tyrosine Kinase Inhibitors
- Kinase Inhibitor
- Tyrosine Kinase Inhibitors
ATC classes
- L01E · PROTEIN KINASE INHIBITORS
Cross-references
Synonyms
- WAY-173606
- bosulif
- bosutinib monohydrate
- bosutinib hydrate
- SKI 606
- SK-606
- SKI-606
- SKI606
- Bosutinib (USAN)
- PF-5208763
- Xy]-3-quinolinecarbonitrile
- 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile
- 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
- 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo
- 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile
- Bosutinib (BCR-ABL inhibitor 3rd gen)
- Bosutinib (SKI-606)
- BOSULIF
- 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
- Bosutinib [USAN]
- SK 606
- BOSUTINIB ISOMER 1
- CHEMBL288441
- 4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile
- CHEBI:39112
- 5018V4AEZ0
- SKI-606)
- Bosutinib (as monohydrate)
- Bosutinib [USAN:INN]
- NCGC00241107-01
- UNII-5018V4AEZ0
- MFCD07367846
- Bosutinib,SKI-606
- BOSUTINIB [INN]
- Bosutinib (SKI606)
- BOSUTINIB [MI]
- BOSUTINIB [VANDF]
Reported adverse events
- Abdominal discomfort
- Abdominal pain
- Abdominal pain lower
- Abdominal pain upper
- Acne
- Amylase increased
- Anaphylactic shock
- Angina unstable
- Arthralgia
- Aspartate aminotransferase
- Asthenia
- Back pain
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