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METOLAZONE
SynDRA canonical compound SYN0002397 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC12A3 |
|---|
| Mechanism of action | Carbonic anhydrase inhibitor |
|---|
| Indication | edema | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
Mechanisms of action (all sources)
- Carbonic anhydrase inhibitor
- SLC12A3 INHIBITOR
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
- SLC12A3 BLOCKER
Drug classes
- Thiazide-like Diuretic
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Chloride Symporter Inhibitors
ATC classes
- C03B · LOW-CEILING DIURETICS, EXCL. THIAZIDES
- DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Cross-references
Synonyms
- SR72022
- zaroxolyn
- metozalone
- Metolazona
- Metazoline
- Metozalone
- Normelan
- Oldren
- NSC-759581
- SR-720-22
- Diulo
- Metenix
- Mykrox
- Xuret
- Zaroxolyn
- Metalazone
- Metalozone
- Metolazonum
- Microx
- Metolazona [INN-Spanish]
- Metolazonum [INN-Latin]
- Mykrox (TN)
- Zaroxolyn (TN)
- Metolazone (JAN/USP/INN)
- Metolazone [USAN:BAN:INN:JAN]
- Mykrox, Zaroxolyn, Diulo, Metolazone
- 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
- 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
- 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide
- 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
- TZ7V40X7VX
- metolazone (usp monograph)
- metolazone (usp-rs)
- metolazone (ep monograph)
- metolazone (ep impurity)
- NSC 759581
- SR 720 22
- DTXCID4025167
Reported adverse events
- Hypersensitivity
- Hepatitis
- Syncope
- Toxic epidermal necrolysis
- Chest pain
- Stevens-Johnson syndrome
- Abdominal discomfort
- Cough
- Dizziness
- Fatigue
- Headache
- Pruritus
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