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BUPROPION
SynDRA canonical compound SYN0002447 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A3 |
|---|
| Mechanism of action | Dopamine uptake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- SLC6A3
- SLC6A4
- ADRA1A
- CHRNA3
- CHRNA7
- CHRNB2
- CHRNB4
- CYP2B6
- CYP2C19
- CYP2D6
- Pgrmc1
Mechanisms of action (all sources)
- Dopamine uptake inhibitor
- SLC6A3 INHIBITOR
- Dopamine transporter inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- dopamine reuptake inhibitor
- SLC6A4 INHIBITOR
Drug classes
- Norepinephrine Uptake Inhibitors
- Dopamine Uptake Inhibitors
- Aminoketone
- Antidepressive Agents
- Antidepressive Agents, Second-Generation
- Central Nervous System Agents
- Cytochrome P-450 CYP2D6 Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Dopamine Agents
- Enzyme Inhibitors
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
ATC classes
- N06A · ANTIDEPRESSANTS
- ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Cross-references
Synonyms
- (+/-)-Bupropion
- amfebutamon
- amfebutamone
- aplenzin
- elontril
- bupropion hydrochloride
- bupropion hydrobromide
- bupropion HCl
- wellbutrin
- Bupropione
- Amfebutamone
- Bupropion extended release
- Bupropion slow release
- NSC-758686
- Amfebutamon
- 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one
- amfebutamonum
- Amfebutamona
- (+-)-Bupropion
- Wellbatrin
- Bupropion [INN:BAN]
- Elontril
- Amfebutamonum [INN-Latin]
- Zyban
- Amfebutamona [INN-Spanish]
- Bupropion SR
- AMFEBUTAMONE HCl
- alpha-(tert-butylamino)-m-chloropropiophenone
- CHEMBL894
- BRN 2101062
- (+-)-1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
- CHEBI:3219
- SNPPWIUOZRMYNY-UHFFFAOYSA-N
- 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]propan-1-one
- Elont
- Bupropion Hcl
- Bupropion hydrocloride
- Bupropion (INN)
Reported adverse events
- Depression
- Depressed mood
- Anxiety
- Constipation
- Dizziness
- Hypertension
- Nausea
- Palpitations
- Pruritus
- Rash
- Tremor
- Insomnia
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