DEXTROMETHORPHAN

SynDRA canonical compound SYN0002452 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	CHRNA2 \| CHRNA3 \| CHRNA4 \| CHRNA7 \| CHRNB2 \| CHRNB4 \| CYBA \| CYBB \| CYP3A5 \| GRIN1 \| GRIN3A \| NCF1 \| NCF2 \| NCF4 \| OPRD1 \| OPRK1 \| OPRM1 \| PGRMC1 \| RAC1 \| RAC2 \| SIGMAR1 \| SLC6A2 \| SLC6A4
Mechanism of action	glutamate receptor antagonist \| sigma receptor agonist
Indication	cough suppressant
Disease area	pulmonary

All known targets

SIGMAR1
SLC6A4
GRIN3A
CHRNA2
RAC1
NCF2
NCF4
OPRD1
OPRK1
OPRM1
PGRMC1
RAC2

Mechanisms of action (all sources)

SIGMAR1 AGONIST
Sigma opioid receptor agonist
GRIN2A ANTAGONIST
Glutamate [NMDA] receptor subunit epsilon 1 antagonist
glutamate receptor antagonist
sigma receptor agonist
CYP19A1 INHIBITOR

Drug classes

Antitussive Agents
Central Nervous System Agents
Excitatory Amino Acid Antagonists
Neurotransmitter Agents
Respiratory System Agents
Uncompetitive NMDA Receptor Antagonists
Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Sigma-1 Receptor Agonists
Sigma-1 Agonist

ATC classes

N07X · OTHER NERVOUS SYSTEM DRUGS
R05D · COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS

Cross-references

PubChem CID: 5360696
ChEMBL: CHEMBL52440
DrugBank: DB00514
ChEBI: CHEBI:4470
KEGG: D00848
RxNorm: 3289
PDB: 4NQ
Wikipedia: Dextromethorphan
TTD: D09OBB
LINCS BRD: BRD-K33211335

Synonyms

Reported adverse events

Dry mouth
Sedation
Respiratory depression
Hallucination
Asthma
Dermatitis
Leukopenia
Neuroleptic malignant syndrome
Depression
Urticaria
Hypotension
Epigastric discomfort

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