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AMILORIDE
SynDRA canonical compound SYN0002720 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
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| Primary target(s) | SCNN1G |
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| Mechanism of action | Sodium channel blocker |
|---|
| Indication | congestive heart failure | hypertension |
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| Disease area | cardiology |
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All known targets
- ASIC1
- SCNN1B
- ASIC2
- SCNN1G
- SCNN1A
- ASIC3
- TRPV2
- TRPC7
- SLC9A5
- SLC9A1
- PKD2L1
- PLAU
Mechanisms of action (all sources)
- Sodium channel blocker
- SCNN1A BLOCKER
- Amiloride-sensitive sodium channel, ENaC blocker
- SCNN1B BLOCKER
- SCNN1G BLOCKER
- ASIC1 MODULATOR
- ASIC2 MODULATOR
- ASIC3 MODULATOR
- SCNN1A|SCNN1B|SCNN1G MODULATOR
- GABRA6 ANTAGONIST
- SLC9A5 INHIBITOR
- TRPC7 MODULATOR
Drug classes
- Potassium-sparing Diuretic
- Acid Sensing Ion Channel Blockers
- Diuretics
- Epithelial Sodium Channel Blockers
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Channel Blockers
ATC classes
- C03D · ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Cross-references
Synonyms
- amiloride hydrochloride
- amiloride hydrochloride anhydrous
- amiloride hydrochloride dihydrate
- amiloride HCl
- Amilorida
- Amiclaran
- Hydro-ride
- Amiloridum
- Amipramidin
- Amipramizid
- Amipramizide
- Amiprazidine
- Amyloride
- Guanamprazin
- Guanamprazine
- Midamor
- Amiloride HCL
- Amiloride hydrochloride hydrate
- Amiclaran (TN)
- Amikal (Hydrochloride dihydrate)
- Amilorida [INN-Spanish]
- Amiloride (INN)
- Amiloride [INN:BAN]
- Amiloridum [INN-Latin]
- Biduret (TN)
- Midamor (Hydrochloride dihydrate)
- MK-870 (Hydrochloride dihydrate)
- AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8))
- N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
- N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
- Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
- 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
- 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
- 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
- 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
- Amiloride (Na-Ca chanel blocker)
- 7DZO8EB0Z3
- midamor
Reported adverse events
- Hyperkalemia
- Nausea
- Nasal congestion
- Nervousness
- Thirst
- Abdominal pain
- Angina pectoris
- Constipation
- Depression
- Dizziness
- Flatulence
- Insomnia
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