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BOSENTAN
SynDRA canonical compound SYN0002782 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | EDNRB |
|---|
| Mechanism of action | Endothelin receptor antagonist |
|---|
| Indication | pulmonary arterial hypertension (PAH) |
|---|
| Disease area | pulmonary |
|---|
All known targets
- EDNRB
- EDNRA
- ABCB1
- ABCB11
- Abcb11
- CYP2C19
- CYP3A4
- Ednra
- Ednrb
- NR1I2
Mechanisms of action (all sources)
- Endothelin receptor antagonist
- EDNRB ANTAGONIST
- Endothelin receptor, ET-A/ET-B antagonist
- EDNRA ANTAGONIST
- EDNRA MODULATOR
- EDNRB MODULATOR
Drug classes
- Endothelin Receptor Antagonists
- Endothelin Receptor Antagonist
- Antihypertensive Agents
- Cardiovascular Agents
- Cytochrome P450 2C9 Inducers
- Cytochrome P450 3A Inducers
ATC classes
- C02K · OTHER ANTIHYPERTENSIVES
Cross-references
Synonyms
- bosentan hydrate
- bosentan monohydrate
- stayveer
- actelion
- tracleer
- bosentan anhydrous
- Bosentan (as monohydrate)
- Bosentan hydrate
- Bosentan monohydrate
- Anhydrous bosentan
- Bosentan anhydrous
- RO-47-0203/029
- RO-47-0203-029
- RO-470203029
- Stayveer
- Tracleer
- Actelion
- Bosentanum
- Bosentan (INN)
- KS-5062
- Ro-47-0203
- Tracleer (TN)
- Bosentan [USAN:INN:BAN]
- Ro-47-0203/039
- Ro-47-0203/029
- P-tert-Butyl-N-[6-(2-hydroxyethoxy)
- P-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
- 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl) benzenesulfornamide
- 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
- 4-t-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide
- p-tert-Butyl-N-(6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl)benzenesulfonamide
- 4-(tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide
- CHEMBL957
- XUL93R30K2
- N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl-benzenesulfonamide
- CHEBI:51450
Reported adverse events
- Hepatotoxicity
- Flushing
- Headache
- Palpitations
- Autoimmune hepatitis
- Rash
- Hypersensitivity
- Nasal congestion
- Syncope
- Thrombocytopenia
- Hypotension
- Neutropenia
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