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LEFLUNOMIDE
SynDRA canonical compound SYN0002788 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DHODH |
|---|
| Mechanism of action | Dihydroorotate dehydrogenase inhibitor |
|---|
| Indication | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- DHODH
- AHR
- CYP1A2
- CYP2C19
- Dhodh
- JAK3
- MAOA
- Malaria DHOdehase
- PTK2B
- SLC28A1
- SLC6A2
- SLC6A3
Mechanisms of action (all sources)
- PDGFR inhibitor
- Dihydroorotate dehydrogenase inhibitor
- DHODH INHIBITOR
- PDGFR tyrosine kinase receptor inhibitor
- Inhibitor
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Immunologic Factors
- Immunosuppressive Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Enzyme Inhibitors
- Antirheumatic Agent
- Dihydroorotate Dehydrogenase Inhibitors
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- leflunomide medac
- arava
- avara
- leflunomida
- leflunomidum
- lefumide
- repso
- Leflunomida
- Leflunomide medac
- Leflunomide ratiopharm
- Leflunomide teva
- Leflunomide winthrop
- Repso
- HWA-486
- L04AA13
- NSC-677411
- NSC-759864
- SU-101
- SU101
- SULOL
- Arava
- Leflunomide zentiva (previously leflunomide winthrop)
- Leflunomid
- Leflunomidum
- Lefunamide
- Aventis Behring Brand of Leflunomide
- Aventis Brand of Leflunomide
- Aventis Pharma Brand of Leflunomide
- Hoechst Brand of Leflunomide
- L 5025
- Arava (TN)
- Arava, Leflunomide
- Leflunomida [INN-Spanish]
- Leflunomide [USAN:INN]
- Leflunomidum [INN-Latin]
- Lefunomide [Inn-Spanish]
- RS-34821
- SU 101 (pharmaceutical)
Reported adverse events
- Hepatotoxicity
- Teratogenicity
- Stevens-Johnson syndrome
- Infection
- Alopecia
- Asthenia
- Bronchitis
- Dizziness
- Headache
- Hypertension
- Interstitial lung disease
- Nausea
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