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TERIFLUNOMIDE
SynDRA canonical compound SYN0002822 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP1A2 | CYP2C8 | DHODH | MMP2 | MMP9 |
|---|
| Mechanism of action | dihydroorotate dehydrogenase inhibitor |
|---|
| Indication | multiple sclerosis |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DHODH
- CYP1A2
- CYP2C8
- DHFR
- Dhodh
- MMP2
- MMP9
- dhod
Mechanisms of action (all sources)
- DHODH INHIBITOR
- Dihydroorotate dehydrogenase inhibitor
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Immunologic Factors
- Immunosuppressive Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Dihydroorotate Dehydrogenase Inhibitors
- Pyrimidine Synthesis Inhibitor
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- HMR1726
- flucyamide
- aubagio
- Teriflunomida
- A77 1726
- HMR-1726
- Aubagio
- Teriflunomide accord
- Teriflunomide mylan
- Leflunomide related compound b
- Leflunomide related compound b rs
- Flucyamide
- A77-1726
- HMR 1726
- (Z)-2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide
- A-771726
- SU 20
- A771726
- (Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
- A 77-1726
- (E/Z)-Teriflunomide
- CHEBI:68540
- Teriflunomide(Random Configuration)
- 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide
- (2z)-2-Cyano-3-Hydroxy-N-[4-(Trifluoromethyl)phenyl]but-2-Enamide
- (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide
- 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)-
- 1C058IKG3B
- 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide
- Teriflunomide (USAN)
- Teriflunomide [INN]
- 2-Butenamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-
- TERIFLUNOMIDE [USAN]
- 2-Cyano-3-OH-N-(4-trifluoromethylphenyl)croton amide
- 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-
- (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide.
- MFCD00910058
- RS-61980
Reported adverse events
- Hepatotoxicity
- Teratogenicity
- Alopecia
- Infection
- Nausea
- Pancreatitis
- Arthralgia
- Headache
- Hypertension
- Interstitial lung disease
- Neutropenia
- Hypersensitivity
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