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ETRAVIRINE
SynDRA canonical compound SYN0003110 — structure-anchored drug synonym record
| Clinical phase | Launched |
| Approval status | Approved · Rx/OTC |
| Primary target(s) | CYP3A4 |
| Mechanism of action | Non-nucleoside reverse transcriptase inhibitor |
| Indication | human immunodeficiency virus (HIV-1) |
| Disease area | infectious disease |
All known targets
- CYP2C19
- CYP2C9
- CYP3A4
- ABCB1
- ABCC1
- ABCC2
- ABCC3
- ABCG2
- HIV RT
- gag-pol
- pol
- reverse transcriptas
Mechanisms of action (all sources)
- Non-nucleoside reverse transcriptase inhibitor
- Modulator
- pol INHIBITOR
Drug classes
- Non-Nucleoside Reverse Transcriptase Inhibitors
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Anti-Infective Agents
- Antiviral Agents
- Enzyme Inhibitors
- Nucleic Acid Synthesis Inhibitors
- Reverse Transcriptase Inhibitors
- Cytochrome P450 2C19 Inhibitors
- P-Glycoprotein Inhibitors
- Cytochrome P450 2C9 Inhibitors
- Cytochrome P450 3A Inducers
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- intelence
- etravirin
- R-165335
- TMC-125
- Etravirina
- R165335
- TMC125
- Intelence
- DAPY deriv
- Diaminopyrimidine deriv
- Intelence (TN)
- Intelence(TM)
- R165335-TMC125
- Etravirine (JAN/USAN/INN)
- TMC-125/R-165335
- 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile
- 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE
- 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
- 65B
- ETR
- R 165335
- TMC 125
- 0C50HW4FO1
- TMC125 cpd
- CHEBI:63589
- etravirinum
- RefChem:57536
- DTXCID40103903
- J05AG04
- Etravirine (TMC125)
- MFCD09837879
- Etravirine-d8
- C20H15BrN6O
- UNII-0C50HW4FO1
- Etravirine CRS
- Etravirine [USAN:INN:BAN:JAN]
- Etravirine [INN]
- Etravine; Etravirine
Reported adverse events
- Rash
- Stevens-Johnson syndrome
- Hepatitis
- Lipase
- Platelet count
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