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BEXAROTENE
SynDRA canonical compound SYN0003202 — structure-anchored drug synonym record
| Clinical phase | Launched |
| Approval status | Approved · Rx/OTC |
| Primary target(s) | RXRG |
| Mechanism of action | Retinoid receptor agonist |
| Indication | cutaneous T-cell lymphoma (CTCL) |
| Disease area | hematologic malignancy |
All known targets
- RXRA
- RXRG
- RXRB
- PPARG
- ABCA1
- RARB
- Rxrb
- Rxra
- RARG
- RARA
- CYP26A1
- NR1H3
Mechanisms of action (all sources)
- Retinoid receptor agonist
- RXRB AGONIST
- Retinoid X receptor agonist
- RXRG AGONIST
- RXRA AGONIST
- PPARG ANTAGONIST
- RXRA MODULATOR
Drug classes
- Antineoplastic Agents
- Retinoid
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- LGD 1069
- targretin
- targretyn
- targrexin
- Bexaroteno
- LG-100069
- LG100069
- LGD-1069
- LGD1069
- NSC-747528
- Targretin
- Targretine
- Bexarotenum
- Targret
- Targretyn
- Targrexin
- Bexarotene [USAN]
- Elan brand of bexarotene;Ligand brand of bexarotene
- LG 1069
- LG1069
- LG69 compound
- Targretin (TN)
- Targretin-gel
- Bexarotene (USAN/INN)
- P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
- 3-methyl-TTNEB
- 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid
- 4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid
- 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
- 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid
- 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid
- 4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid
- 9RA
- 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
- p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
- 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid
- NSC 747528
- CHEMBL1023
Reported adverse events
- Headache
- Infection
- Rash
- Alopecia
- Cataract
- Chills
- Hypothyroidism
- Insomnia
- Nausea
- Vomiting
- Asthenia
- Leukopenia
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