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ACITRETIN
SynDRA canonical compound SYN0003952 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | RARA | RARB | RARG | RBP1 | RXRA | RXRB | RXRG | STAT3 |
|---|
| Mechanism of action | retinoid receptor agonist |
|---|
| Indication | psoriasis |
|---|
| Disease area | dermatology |
|---|
All known targets
- RARA
- RARG
- RARB
- RXRA
- RXRB
- RXRG
- STAT3
- ABCB11
- Abcb11
- RBP1
Mechanisms of action (all sources)
- RXRB AGONIST
- Retinoid receptor agonist
- RARG AGONIST
- RXRG AGONIST
- RARB AGONIST
- RARA AGONIST
- RXRA AGONIST
- STAT3 INHIBITOR
Drug classes
- Retinoid
- Dermatologic Agents
- Keratolytic Agents
ATC classes
- D05B · ANTIPSORIATICS FOR SYSTEMIC USE
Cross-references
Synonyms
- acitretinoin
- etretin
- neotigason
- soriatane
- isoacitretin
- isoetretin
- Acitretine
- Acitretina
- Etretin
- RO 10-1670
- RO-10-1670/000
- RO-101670000
- Ro-10-1670-000
- Neotigason
- Soriatane
- Acitretinum
- Isoacitretin
- Isoetretin
- TMMP
- Acitretina [Spanish]
- Acitretine [French]
- Acitretinum [Latin]
- Retinoid etretin
- U0279
- Ro-10-1670
- Ro-13-7652
- Soriatane (TN)
- Soriatane, Acitretin
- Acitretin (USAN/INN)
- Acitretin [USAN:INN:BAN]
- All-trans-Acitretin
- Ro-10-1670/000
- All-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid
- (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid
- (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
- (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
- 13-cis-Acitretin
- 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
Reported adverse events
- GI malformation
- Hepatotoxicity
- Dysphonia
- Arthralgia
- Cheilitis
- Dizziness
- Dry mouth
- Flushing
- Headache
- Jaundice
- Stomatitis
- Conjunctivitis
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