DULOXETINE

SynDRA canonical compound SYN0004288 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	SLC6A4
Mechanism of action	Norepinephrine reuptake inhibitor
Indication	depression \| generalized anxiety disorder (GAD) \| muscle pain \| peripheral neuropathy
Disease area	neurology/psychiatry

All known targets

SLC6A4
SLC6A2
SLC6A3
HTR6
HTR2A
HTR2C
HTR7
Slc6a3
SHMT2
NET
HRH1
HTR1A

Mechanisms of action (all sources)

Serotonin reuptake inhibitor
Norepinephrine reuptake inhibitor
SLC6A4 INHIBITOR
Serotonin transporter inhibitor
SLC6A2 INHIBITOR
Norepinephrine transporter inhibitor
serotonin–norepinephrine reuptake inhibitor (SNRI)

Drug classes

Norepinephrine Uptake Inhibitors
Serotonin Uptake Inhibitors
Analgesics
Antidepressive Agents
Central Nervous System Agents
Dopamine Agents
Membrane Transport Modulators
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Peripheral Nervous System Agents
Psychotropic Drugs
Sensory System Agents

ATC classes

N06A · ANTIDEPRESSANTS

Cross-references

PubChem CID: 60835
ChEMBL: CHEMBL1175
DrugBank: DB00476
ChEBI: CHEBI:31526
KEGG: D01179
RxNorm: 72625
PDB: 29E
Wikipedia: Duloxetine
TTD: D01AXB
LINCS BRD: BRD-K71103788

Synonyms

Reported adverse events

Mania
Dizziness
Headache
Insomnia
Nausea
Syncope
Agitation
Vomiting
Fatigue
Tremor
Constipation
Dyspepsia

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