ISOFLURANE

SynDRA canonical compound SYN0004856 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	GABRA1 \| GABRA2 \| GABRA3 \| GABRA4 \| GABRA5 \| GABRA6 \| GABRB1 \| GABRB2 \| GABRB3 \| GABRD \| GABRE \| GABRG1 \| GABRG2 \| GABRG3 \| GABRP \| GABRQ \| GLRA1 \| GLRB \| KCNK10 \| KCNK18 \| KCNK2 \| KCNK3 \| KCNK9
Mechanism of action	inhaled anaesthetic
Indication	general anaesthetic
Disease area	neurology/psychiatry

All known targets

KCNK2
KCNK9
KCNK3
KCNK18
KCNK10
GLRB
GLRA1
GABRA2
GABRQ
GABRP
GABRG3
GABRA1

Mechanisms of action (all sources)

GLRA1 POSITIVE MODULATOR
Glycine receptor (alpha-1/beta) positive modulator
GLRB POSITIVE MODULATOR
KCNK10 OPENER
Potassium channel subfamily K member 10 opener
KCNK18 OPENER
Potassium channel subfamily K member 18 opener
KCNK3 OPENER
Potassium channel subfamily K member 3 opener
KCNK9 OPENER
Potassium channel subfamily K member 9 opener
KCNK2 OPENER

Drug classes

Anesthetics
Anesthetics, Inhalation
Central Nervous System Agents
Central Nervous System Depressants
General Anesthetic

ATC classes

N01A · ANESTHETICS, GENERAL

Cross-references

PubChem CID: 3763
ChEMBL: CHEMBL1256
DrugBank: DB00753
ChEBI: CHEBI:6015
KEGG: D00545
RxNorm: 6026
Wikipedia: Isoflurane
TTD: D0DP6L

Synonyms

Reported adverse events

Cardiac arrest
Agitation
Anaphylactic reaction
Blood bilirubin increased
Blood glucose increased
Bronchospasm
Chills
Delirium
Hepatic failure
Hepatic necrosis
Hypotension
Laryngospasm

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