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TOLCAPONE

SynDRA canonical compound SYN0005279 — structure-anchored drug synonym record

All known targets

• COMT
• TTR
• Abcb11
• Comt
• GPR35
• KLF10

Mechanisms of action (all sources)

• Catechol O methyltransferase inhibitor
• COMT INHIBITOR
• Catechol O-methyltransferase inhibitor

Drug classes

• Anti-Dyskinesia Agents
• Antiparkinson Agents
• Catechol O-Methyltransferase Inhibitors
• Central Nervous System Agents
• Enzyme Inhibitors
• Catechol-O-Methyltransferase Inhibitor

ATC classes

• N04B · DOPAMINERGIC AGENTS

Cross-references

• PubChem CID: 4659569
• ChEMBL: CHEMBL1324
• DrugBank: DB00323
• ChEBI: CHEBI:63630
• KEGG: D00786
• RxNorm: 72937
• PDB: TCW
• Wikipedia: Tolcapone
• TTD: D0Y7PG
• LINCS BRD: BRD-K10852020

Synonyms

• RO 40-7592
• tasmar
• Tolcapona
• RO-40-7592
• RO-407592
• Tasmar
• Roche brand of tolcapone
• Ro-40-7592
• Tasmar (TN)
• Tolcapone [USAN:INN]
• Tolcapone (JAN/USAN/INN)
• Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)
• (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
• (3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
• 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
• 3,4-dihydroxy-5'-methyl-5-nitrobenzophenone
• Ro 40 7592
• CIF6334OLY
• tolcapone (usp monograph)
• Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
• Ro 407592
• tolcapone (usp-rs)
• 5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol
• DTXCID903685
• 3,4-dihydroxy-5-nitro-4'-methylbenzophenone
• 4'-methyl-3,4-dihydroxy-5-nitrobenzophenone
• CHEBI:63630
• 5-((4-methylphenyl)carbonyl)-3-nitrobenzene-1,2-diol
• Tolcaponum
• 5-[(4-METHYLPHENYL)CARBONYL]-3-NITROBENZENE-1,2-DIOL
• Ro407592
• Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
• RefChem:57103
• 3,4 Dihydroxy 5' methyl 5 nitrobenzophenone
• N04BX01
• (3,4-dihydroxy-5-nitrophenyl)(p-tolyl)methanone
• MFCD00866569
• s4021

Reported adverse events

• Rhabdomyolysis
• Agitation
• Alopecia
• Arthritis
• Cataract
• Constipation
• Dizziness
• Dyskinesia
• Dyspepsia
• Dystonia
• Fall
• Fatigue