LOMITAPIDE

SynDRA canonical compound SYN0005399 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	MTTP
Mechanism of action	Microsomal trigylceride transfer protein inhibitor
Indication	hypercholesterolemia
Disease area	endocrinology

All known targets

MTTP
CYP2B6
CYP2C19
CYP2C8
P4HB

Mechanisms of action (all sources)

Microsomal trigylceride transfer protein inhibitor
MTTP INHIBITOR
Microsomal triglyceride transfer protein inhibitor
P4HB INHIBITOR

Drug classes

Cytochrome P450 3A4 Inhibitors
P-Glycoprotein Inhibitors
Microsomal Triglyceride Transfer Protein Inhibitors
Microsomal Triglyceride Transfer Protein Inhibitor

ATC classes

C10A · LIPID MODIFYING AGENTS, PLAIN

Cross-references

PubChem CID: 9853053
ChEMBL: CHEMBL354541
DrugBank: DB08827
ChEBI: CHEBI:72297
KEGG: D09637
RxNorm: 1364479
Wikipedia: Lomitapide
TTD: D0H8VY
LINCS BRD: BRD-K92213669

Synonyms

juxtapid
BMS 201038
lomitapide mesylate
lojuxta
lomitapide mesilate
BMS201038
Lomitapida
AEGR-733
BMS-201038-01
Lojuxta
AEGR733
BMS 201238
BMS 201038-01
AEGR 733
Juxtapid
AEGR-733(Lomitapide)
Lomitapide free base
AEGR-733;BMS-201038
CHEMBL354541
CHEBI:72297
82KUB0583F
182431-12-5 (free base)
n-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide
9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-1-piperidinyl)butyl)-
N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide
Lomitapide [USAN]
Lomitapide [USAN:INN]
lomitapida
lomitapidum
UNII-82KUB0583F
HSDB 8218
9H-Fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-
N-(2,2,2-TRIFLUOROETHYL)-9-(4-(4-(((4'-(TRIFLUOROMETHYL)BIPHENYL-2-YL)CARBONYL)AMINO)PIPERIDIN-1-YL)BUTYL)-9H-FLUORENE-9-CARBOXAMIDE
N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido]piperidin-1-yl]butyl]-9H-fluorene-9-carboxamide
LOMITAPIDE [MI]

Reported adverse events

Hepatic steatosis
Abdominal discomfort
Abdominal distension
Abdominal pain
Alopecia
Chest pain
Constipation
Dizziness
Dyspepsia
Fatigue
Flatulence
Gastroenteritis

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