← SynDRA

PALBOCICLIB

SynDRA canonical compound SYN0005849 — structure-anchored drug synonym record

All known targets

• CDK4
• CDK6
• CCND1
• AAK1
• JAK3
• TAOK2
• STK16
• RPS6KA1
• PRKD3
• PRKD2
• PIP4K2C
• PIP4K2A

Mechanisms of action (all sources)

• cyclin-dependent kinase inhibitor
• CCND1 INHIBITOR
• CDK6/cyclin D1 inhibitor
• CDK4/6 inhibitor
• Cyclin-dependent kinase 4/cyclin D1 inhibitor
• CDK4 MODULATOR
• CDK6 MODULATOR

Drug classes

• Kinase Inhibitors
• Antineoplastic Agents
• Enzyme Inhibitors
• Protein Kinase Inhibitors
• Kinase Inhibitor
• Cytochrome P450 3A Inhibitors

ATC classes

• L01E · PROTEIN KINASE INHIBITORS

Cross-references

• PubChem CID: 5330286
• ChEMBL: CHEMBL189963
• DrugBank: DB09073
• ChEBI: CHEBI:85993
• KEGG: D10372
• RxNorm: 1601374
• PDB: LQQ
• Wikipedia: Palbociclib
• TTD: D00UZR
• LINCS BRD: BRD-K51313569

Synonyms

• palbociclib isethionate
• ibrance
• PD 0332991
• PD-0332991-0054
• PF-00080665-73
• Ibrance
• Palbociclib isethionate
• PALBOCICLIBPD-0332991PD0332991IBRANCECS-0019A-1030
• PD-0332991
• PD-03329910054
• PD0332991
• PF-0008066573
• PFE-PKIS 32
• PFE-PKIS_32
• UNII-G9ZF61LE7G
• Palbociclib(PD0332991)
• 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
• 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
• G9ZF61LE7G
• PD 332991
• 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
• LQQ
• PD 332991, PD 0332991, PD0332991
• 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
• 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
• HMR-2934
• Palbociclib free base
• 571190-30-2 (free base)
• MFCD11840850
• CHEBI:85993
• 2euf
• 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
• Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)-
• Palbociclib [USAN]
• 571190-30-2 pound not827022-32-2
• Palbociclib [USAN:INN]
• [d8]-Palbociclib
• 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-((5-(PIPERAZIN-1-YL)PYRIDIN-2-YL)AMINO)-8H-PYRIDO(2,3-D)PYRIMIDIN-7-ONE

Reported adverse events

• Alopecia
• Asthenia
• Blood creatinine
• Blood creatinine increased
• Dry skin
• Dysgeusia
• Fatigue
• Infection
• Interstitial lung disease
• Leukopenia
• Nausea
• Neutropenia