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PROGUANIL
SynDRA canonical compound SYN0005858 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
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| Primary target(s) | CYP2C19 | DHFR |
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| Mechanism of action | dihydrofolate reductase inhibitor |
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| Indication | malaria |
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| Disease area | infectious disease |
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All known targets
Mechanisms of action (all sources)
- dihydrofolate reductase inhibitor
- PDF INHIBITOR
Drug classes
- Dihydrofolate Reductase Inhibitors
- Antimalarial
- Anti-Infective Agents
- Antimalarials
- Antimetabolites
- Antiparasitic Agents
- Antiprotozoal Agents
- Noxae
ATC classes
Cross-references
Synonyms
- proguanil hydrochloride
- chloroguanide
- chloroguanide hydrochloride
- proguanil HCl
- chloroguanide HCl
- Chlorguanide
- Chloroguanide
- Bigumal
- Chlorguanid
- Chloriguane
- Paludrin
- Proguanile
- Proguanilum
- Proguanile [DCIT]
- Diguanyl (hydrochloride)
- Drinupal (hydrochloride)
- Paludrine (TN)
- Paludrine (hydrochloride)
- Palusil (hydrochloride)
- Proguanil [INN:BAN]
- Proguanilum [INN-Latin]
- RP-3359
- Tirian (hydrochloride)
- M-4888 (hydrochloride)
- SN-12837 (hydrochloride)
- N1-p-Chlorophenyl-N5-isopropylbiguanide
- N-(4-Chlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide
- N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide
- N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
- (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
- 1-(p-Chlorophenyl)-5-isopropylbiguanide
- 1-Isopropyl-5-(4-chlorophenyl)biguanide
- MFCD00866201
- N1-(4-Chlorophenyl)-N5-isopropylbiguanide
- Proguanil?
- SCHEMBL45726
- SCHEMBL45727
- SCHEMBL45728
Reported adverse events
- Anxiety
- Dizziness
- Insomnia
- Nausea
- Pruritus
- Vomiting
- Abdominal pain
- Depression
- Headache
- Neutropenia
- Pancytopenia
- Stevens-Johnson syndrome
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