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ROFLUMILAST
SynDRA canonical compound SYN0005877 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PDE4D |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
| Indication | bronchitis | chronic obstructive pulmonary disease (COPD) |
|---|
| Disease area | pulmonary |
|---|
All known targets
- PDE4B
- PDE4A
- PDE4C
- PDE4D
- CYP2B6
- CYP2C19
- PDEB1
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- PDE4A INHIBITOR
- Phosphodiesterase 4 inhibitor
- PDE4D INHIBITOR
- PDE4B INHIBITOR
- PDE4C INHIBITOR
Drug classes
- Phosphodiesterase 4 Inhibitors
- Phosphodiesterase 4 Inhibitor
ATC classes
- R03D · OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
- D05A · ANTIPSORIATICS FOR TOPICAL USE
Cross-references
Synonyms
- libertek
- daxas
- daliresp
- BY217
- B9302-107
- BYK20869
- Arq-151
- Zoryve
- ARQ-154 (ROFLUMILAST FOAM)
- B-9302-107
- BY-217
- BYK-20869
- Daliresp
- Daxas
- Libertek
- DAXAS
- 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE
- UNII-0P6C6ZOP5U
- Roflumilast (Daxas)
- 0P6C6ZOP5U
- 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
- Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-
- CHEMBL193240
- CHEBI:47657
- ROF
- AK110425
- 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
- Roflumilast [USAN]
- APTA-2217
- Roflumilast (JAN/USAN/INN)
- 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-di-chloropyrid-4-yl)benzamide
- Alogliptin/roflumilast
- ARQ-151
- ZORYVE
- ARQ-154 (Roflumilast foam)
- B 9302-107
- BYK 20869
- BY 217
Reported adverse events
- Dizziness
- Headache
- Insomnia
- Nausea
- Back pain
- Weight decreased
- Decreased appetite
- Influenza
- Gastrointestinal disorder
- Weight
- Infection
- Infestation
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