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RG-547

SynDRA canonical compound SYN0006379 — structure-anchored drug synonym record

All known targets

• CDK1
• CDK2
• CDK4
• CDK7

Mechanisms of action (all sources)

• CDK1 INHIBITOR
• Cyclin-dependent kinase 1 inhibitor
• CDK2 INHIBITOR
• Cyclin-dependent kinase 2 inhibitor
• CDK4/6 inhibitor
• Cyclin-dependent kinase 4 inhibitor
• CDK4 INHIBITOR
• CDK7 INHIBITOR

Cross-references

• PubChem CID: 6918852
• ChEMBL: CHEMBL384304
• DrugBank: DB08094
• ChEBI: 43844
• PDB: LIA
• TTD: D04FHB
• LINCS BRD: BRD-K52233191

Synonyms

• R 547
• Ro-4584820
• RO4584820
• R547
• LIA
• R-547
• [4-amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone
• (4-amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
• Ro 4584820
• [4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
• T61871RKRI
• 741713-40-6 (free base)
• (4-Amino-2-((1-methylsulfonylpiperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
• 5-[(2,3-difluoro-6-Methoxyphenyl)carbonyl]-2-N-(1-Methanesulfonylpiperidin-4-yl)pyriMidine-2,4-diaMine
• (4-Amino-2-{[1-(Methylsulfonyl)piperidin-4-Yl]amino}pyrimidin-5-Yl)(2,3-Difluoro-6-Methoxyphenyl)methanone
• 4-Amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone
• UNII-T61871RKRI
• 2fvd
• (4-amino-2-([1-(methylsulfonyl)piperidin-4-yl]amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone
• MLS006010282
• CHEMBL384304
• GTPL5707
• SCHEMBL2397067
• BDBM12621
• DTXSID30225143
• EX-A105
• HMS3656L13
• 2,4-Diamino-5-ketopyrimidine 39
• BCP02856
• MFCD09970629
• NSC773094
• NSC800859
• s2688
• ZINC13983251
• AKOS025149095
• CCG-269137
• CS-0022
• DB08094