HYDROCORTISONE

SynDRA canonical compound SYN0006808 — structure-anchored drug synonym record

Clinical phase	Launched
Approval status	Approved · Rx/OTC
Primary target(s)	NR3C1
Mechanism of action	Glucocorticoid receptor agonist
Indication	eczema \| itching \| psoriasis \| seborrheic dermatitis
Disease area	dermatology \| neurology/psychiatry

All known targets

NR3C1
ANXA1
NOS2
NR3C2
SERPINA6
SHBG

Mechanisms of action (all sources)

NR3C1 AGONIST

Drug classes

Corticosteroid Hormone Receptor Agonists
Corticosteroid
Anti-Inflammatory Agents

ATC classes

A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
S01B · ANTIINFLAMMATORY AGENTS
D07A · CORTICOSTEROIDS, PLAIN
A01A · STOMATOLOGICAL PREPARATIONS
R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
S02B · CORTICOSTEROIDS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS

Cross-references

PubChem CID: 5754
ChEMBL: CHEMBL389621
DrugBank: DB00741
ChEBI: CHEBI:17650
KEGG: D00088
RxNorm: 5492
PDB: HCY
Wikipedia: Cortisol
LINCS BRD: BRD-K93568044

Synonyms

Reported adverse events

Ototoxicity
Cushingoid
Sodium retention
Hypertension
Exophthalmos
Tendon rupture
Fluid retention
Vertigo
Perioral dermatitis
Epidural lipomatosis
Central serous chorioretinopathy
Hypertrichosis

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