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EFAVIRENZ
SynDRA canonical compound SYN0006825 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | HIV protease inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
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All known targets
- CYP3A4
- CYP2B6
- CYP2C19
- CYP2C9
- CYP2D6
- CYP1A2
- ABCG2
- env
- reverse transcriptas
- pol
- gag-pol
- CYP3A5
Mechanisms of action (all sources)
- protease inhibitor
- Modulator
- pol INHIBITOR
Drug classes
- Non-Nucleoside Reverse Transcriptase Inhibitors
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Anti-Infective Agents
- Antiviral Agents
- Cytochrome P-450 CYP2B6 Inducers
- Cytochrome P-450 CYP2C19 Inhibitors
- Cytochrome P-450 CYP2C9 Inhibitors
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Metabolic Side Effects of Drugs and Substances
- Nucleic Acid Synthesis Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- stocrin
- (-)-efavirenz
- sustiva
- Efavirenz teva
- Efavirenzum
- Stocrin
- Viraday
- DMP-266
- L-743726
- NSC-742403
- Efavirenz component of atripla
- Efavirenz component of symfi
- Efavirenz component of telura
- Sustiva
- Sustiva 600
- EFV
- EFZ
- Eravirenz
- L-741211
- L-743725
- Stocrin (TN)
- Strocin (TM)
- Sustiva (TM)
- Sustiva (TN)
- Efavirenz (JAN/INN)
- L-743,726
- Zoxazin-2-one
- Efavirenz, (S)-isomer
- Met-SDF-1.beta. & Efavirenz
- Met-Stromal Cell-derived Factor-1.beta. (Human) & Efavirenz
- (-)-Efavirenz
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
- (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-ben
- (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
Reported adverse events
- Lactic acidosis
- Rash
- Stevens-Johnson syndrome
- Fanconi syndrome
- Anxiety
- Depression
- Dizziness
- Headache
- Hepatotoxicity
- Insomnia
- Nausea
- Pancreatitis
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