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APREPITANT
SynDRA canonical compound SYN0007629 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TACR1 |
|---|
| Mechanism of action | Tachykinin antagonist |
|---|
| Indication | nausea | vomiting |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- TACR1
- CYP2C19
- CYP3A4
- TACR3
Mechanisms of action (all sources)
- Tachykinin antagonist
- TACR1 ANTAGONIST
- Neurokinin 1 receptor antagonist
Drug classes
- Neurokinin 1 Antagonists
- Antiemetics
- Central Nervous System Agents
- Gastrointestinal Agents
- Neurokinin-1 Receptor Antagonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Substance P/Neurokinin-1 Receptor Antagonist
- Cytochrome P450 3A4 Inhibitors
- Cytochrome P450 3A4 Inducers
- Cytochrome P450 2C9 Inducers
ATC classes
- A04A · ANTIEMETICS AND ANTINAUSEANTS
Cross-references
Synonyms
- emend
- L-754030
- ONO-7436
- Aponvie
- APREPITANT (MK-0869)
- APREPITANT`
- Cinvanti
- Emend
- L-754,030
- MK-0869
- MK-869
- NSC-748825
- Aprepitant [USAN]
- Emend (TN)
- Aprepitant (JAN/USAN/INN)
- MK-869, L-754030, Emend, Aprepitant
- 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-Delta(2)-1,2,4-triazolin-5-one
- 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(sup 2)-1,2,4-triazolin-5-one
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
- 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
- 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
- NSC 748825
- L 754,030
- aprepitant (usp monograph)
- 1NF15YR6UY
- aprepitant (usp-rs)
- MK 869
- ONO 7436
- MK 0869
- aprepitant (ep monograph)
- L 754030
- aprepitantum
- CHEBI:499361
- DTXCID801021794
- RefChem:57104
- A04AD12
- MK869
- MK0517
Reported adverse events
- Infection
- Stevens-Johnson syndrome
- Angioedema
- Asthenia
- Bradycardia
- Constipation
- Dizziness
- Fatigue
- Headache
- Hiccups
- Tinnitus
- Infestation
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